noun (n)

• an exasperated feeling of annoyance(noun.feeling)

  Synonym:
  exasperation
  

  source: wordnet30
• unfriendly behavior that causes anger or resentment(noun.act)

  Synonym:
  irritation, provocation
  

  source: wordnet30
• action that makes a problem or a disease (or its symptoms) worse(noun.act)

  Example:
  The aggravation of her condition resulted from lack of care.
  

  Synonym:
  exacerbation
  

  source: wordnet30
• The act of aggravating, or making worse; -- used of evils, natural or moral; the act of increasing in severity or heinousness; something additional to a crime or wrong and enhancing its guilt or injurious consequences.(noun)

  source: webster1913